内皮素-1（Endothelin-1 ）ELISA kit

灵敏、快速的内皮素-1 ELISA试剂盒，适用于心血管和应激相关研究

内皮素（Endothelin, ET）是由血管内皮细胞产生的异肽，具有强大的血管收缩活性。这种肽由三个独立的基因编码，经过加工产生39个残基的 '大ET '分子，再进一步加工成21个氨基酸序列，命名为ET-1、ET-2和ET-3。ET的作用是通过与两个受体（ETA和ETB）的结合来介导的。ETA的激活会增加血管收缩和钠潴留，从而增加血压。ETB受体的激活引发血管舒张因子的释放，如内皮细胞的一氧化氮（NO）和前列腺素，并增加尿液的产生和排出，从而降低血压。

欣博盛生物作为Enzo Life Sciences授权中国一级代理，可提供该产品，欢迎咨询。

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产品特点

◆ 高灵敏度，可检测低至0.41pg/ml的ET-1，正常和病理样本均可检测

◆ 高通量，仅需2小时就能得到38份样本（含复孔）的检测结果

◆ 可灵活选择过夜或1小时孵育

◆ 适用于多种样本类型

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产品信息

产品货号	ADI-900-020A / 欣博盛生物
产品名称	Endothelin-1 ELISA kit（内皮素-1 ELISA试剂盒）
规格	96 wells
灵敏度	0.41 pg/ml
检测范围	0.78 - 100 pg/ml
应用	ELISA, Colorimetric detection
适用样本类型	For the quantitative determination of ET-1 in culture supernatants, plasma,? and serum of human, mouse, rat, cow, dog, pig, and rabbit origin.? Cited sample types include cell lysates and tissue homogenates.
检测波长	450 nm
适用种属	Human, Mouse, Rat Bovine, Dog, Porcine, Rabbit
运输	Blue Ice Not Frozen
长期保存	+4°C
试剂盒组分	Microtiter plate, Antibody diluent, Antibody concentrate, Assay buffer 17,? Wash buffer concentrate, Standard, TMB Substrate, Stop solution 2

标准曲线示例

部分产品引用文献

1.?NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption: O. Germande, et al.; Nanotoxicology 16, 29 (2022)

2.?Treatment with apocynin selectively restores hippocampal arteriole function and seizure-induced hyperemia in a model of preeclampsia: M.J. Cipolla, et al.; J. Cereb. Blood Flow Metab. (2022)

3.?Vasorin plays a critical role in vascular smooth muscle cells and arterial function: L. Louvet, et al.; J. Cell. Physiol. 237, 3845 (2022)

4.?Contributions of Sodium-Hydrogen Exchanger-1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes: Y.L. Chen, et al.; Diabetes 70, 2353 (2021)

5.?Dehulled Adlay Consumption Modulates Blood Pressure in Spontaneously Hypertensive Rats and Overweight and Obese Young Adults: W.-J. Jeh, et al.; Nutrients 13, 2305 (2021)

6.?Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial: T.V. Dam, et al.; Menopause 28, 1214 (2021)

7.?Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities: J. van de Wouw, et al.; Basic Res. Cardiol. 116, 51 (2021)

8.?Anthocyanin-Rich New Zealand Blackcurrant Extract Supports the Maintenance of Forearm Blood-Flow During Prolonged Sedentary Sitting: M.J. Barnes, et al.; Front. Nutr. 7, 74 (2020)

9.?Aerobic exercise training improves insulin-induced vasorelaxation in a vessel-specific manner in rats with insulin-treated experimental diabetes: M.W. McDonald, et al.; Diab. Vasc. Dis. Res. 16, 77 (2019)

10.?Chronic consumption of a low calorie, high polyphenol cranberry beverage attenuates inflammation and improves glucoregulation and HDL cholesterol in healthy overweight humans: a randomized controlled trial: B. Chew, et al.; Eur. J. Nutr. 58, 1223 (2019)

11.?Gelatin-based perfusable, endothelial carotid artery model for the study of atherosclerosis: R. Chen, et al.; Biomed. Eng. Online 18, 87 (2019)

12.?Hyperglycemia enhances constriction of retinal venules via activation of the reverse-mode sodium-calcium exchanger: Y.L. Chen, et al.; Diabetes 68, 1624 (2019)

13.?In Vivo Comparative Study on Acute and Sub-acute Biological Effects Induced by Ultrafine Particles of Different Anthropogenic Sources in BALB/c Mice: F. Farina, et al.; Int. J. Mol. Sci. 20, 2805 (2019)

14.?Co-ingestion of whole eggs or egg whites with glucose protects against postprandial hyperglycaemia-induced oxidative stress and dysregulated arginine metabolism in association with improved vascular endothelial function in prediabetic men: J.D. McDonald, et al.; Br. J. Nutr. 120, 901 (2018)

15.?Effects of Personal Short-Term Exposure to Ambient Ozone on Blood Pressure and Vascular Endothelial Function: A Mechanistic Study Based on DNA Methylation and Metabolomics: Y. Xia, et al.; Environ. Sci. Technol. 52, 12774 (2018)

16.?Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells: H.C. Lin, et al.; Environ. Toxicol. 32, 918 (2017)

17.?Renoprotective effects of montelukast in an experimental model of cisplatin nephrotoxicity in rats: A.M. Gad, et al.; J. Biochem. Mol. Toxicol. 31, (2017)

18.?Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt: A. Wannhoff, et al.; Aliment. Pharmacol. Ther. 43, 955 (2016)